Analysis of the functional alterations induced by microgravity in human satellite cells SCs. Obesity and immune functions, Natural Killer cell disfunction alter cancer growth. Neurodegenerative diseases: Animal models. Molecular diagnostic of Trichomona vaginalis in Pregnant and non pregnant women from Pedregal, District , Panam.
Effect of Vitamin D and antioxidants in vascular function. Staphylococcus aureus colonization and infection. Biochemistry of intracellular transport: Biogenesis and autophagic degradation of Peroxisomes. Molecular interactions underlying the growth and regeneration of central and peripheral nervous system axons. Investigation of Angiostrongyliasis and Schistosomiasis. Immune tolerance in the immunosuppressive phase in sepsis. Inflammation-induced bone destruction in vitro and in vivo: from mechanistic investigation to therapeutic potentials.
Modeling and Analysis of Infectious Diseases in the Age of globalization. Ultrasound imaging technique: experiments, programming, and data analysis. Medical Genomics and Precision Medicine with molecular studies of cancer cells. Tumoral microenvironment: Immunohistochemistry M1 and M2 macrophage and its relationship with prognostic and predictive factors.
Extracellular vesicles: a mirror of cardiovascular diseases? Neuroinflammation and neurodegeneration. Possible anti-inflammatory andanalgesic activity of Dasyatisamericana venom. Spaciotemporal analysis of immune responses in virus infection and tumor in animal models. Functional analysis of cardiac ion channels under physiological and pathophysiological conditions. Neuronal organization in brain areas possibly involved in animal cognition. The genomic basis of immunological responses in prostate and kidney cancer.
The role of the immune system in heart failure HF. Research of multilayer polyelectrolyte microcapsules uptake influence on adhesion and migration activity of mesenchymal stem cells. Disorders related to the intake of gluten. Biochemical and Molecular Markers. Exploring serine proteases inhibitors from traditional Chinese medicines. Investigation of skin microbiome in atopic dermatitis. Developmental programming by gestational diabetes: focus on microglia as dynamic mediators of synapse formation.
Development of depression and changes in activation of hypothalamic-pituitary-adrenal HPA axis in Wistar rat. The Aryle hydrocarbone hydroxylase gene polymorphism in smoker and non-smoker individuals in Canakkale population. Antimicrobial synergism against bacteria isolated from clinical specimens. To explore the role of Runx1 in the biological functions of Clara cells and in the Clara cell involved lung diseases.
Pre-leukemie chromosome aberrations in Fanconi anemia cells: prognostic implications. G-quadruplex aptamers for cervical cancer therapy: structure, function and application. Positron emission tomography PET in combination with computed tomography CT : Analysis of results in endemic areas of granulomatous diseases. Deuterium primary isotope effect on bio chemical reactions and cell growth. Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression.
How do bacteria protect their envelope: opening the ways to the design of new antibiotics. Setting up of a gamete donation program. Evaluation of choroid on diabetic retinopathy. Molecular determinants of autophagy modulating reagents for cancer therapy. Identification of circadian rhythm related proteins expression changes in colorectal Carcinoma.
Secondary Data Analysis in Medical Research. Radium for Metastatic Prostate Cancer. An attempt to see beyond what is known. Risk factors for the development of early adverse events in elderly cancer patients: a prospective cohort study. Evaluation of the effect of different factors on extracting forensic evidence in rape. Role of astrocytes in synaptic and memory dysfunction in Alzheimers disease. Neuron-microglia communication: role of carbon monoxide on modulation of neuroinflammation and neuroprotection. Functional and molecular imaging of neurodevelopmental and neurodegenerative disorders.
Identification of New Drugs to Delay Atherosclerosis. Electron microscopic analysis of autophagy in tumors and metabolic disorders. Testing of health safety of dietary supplements. Role of tyrosine kinase-mediated signaling pathways in cardiovascular diseases heart failure, atherosclerosis, pulmonary hypertension. Translacional bigenomics investigation in Lebers hereditary optic neuropathy: genothype-phenotype correlation.
The role of galectin 3 in acute colitis. Bisphenol A effect on hepatic Growth hormone actions. Exploring the effects of some hormones with antioxidant potential on induction and complications of experimentally induced type 2 diabetes mellitus. Changes of brain proteome composition and thermodynamic properties in neurodegenerative disorders relation of proteome exothermic process with the mechanism of plaque formation.
Cervical spine anterior longitudinal ligament ossification in Omani population: a cross sectional study. Risk of diseases following medical interventions. How does preeclampsia affect long-term maternal health outcomes? Testing compounds that can selectively kill aneuploid cells. Promoting shared decision-making in Vascular Surgery. Establish precise medical model of diagnosis and treatment of colorectal clinical studies based on detection of ctDNA liquid biopsy technique. From neuroinflammation control to neuroprotection - identification of targets and mechanisms behind retinal neurodegeneration.
Characterization of the host immune response to Candida species cells. Molecular analysis for subgroups of prostate and kidney cancer. Bucharest Emergence of carbapenemase-producing strains of enterobacteriaceae and their impact on antimicrobial therapy. Study of major diseases in oncology, endocrinology and cardiology. Morphological markers of human and experimental animals liver cells within its organization during development.
Sprouty Proteins as modulators of signaling in lung cancer. Gene signatures associated with the pathogenesis of the Metabolic Syndrome in mice. The role of the mRNA degradation machinery in neurodegeneration. Isolation of protozoan specific viruses from natural environments. Investigation of the therapeutic effects of natural products with vegetable origin on the side effects of antineoplastic drugs. Neural bases of Sleep and Wake Cycle and your importance to human health. Hypoxia Inducible Factor 1 alpha HIF1A transcription factor as a model substrate to study selective protein loading into exosomes.
Role of the protocadherin-gamma protein family at the blood-brain barrier. Benign and malignant pathology of nose and paranasal cavities. The impact of 24 hour ambulatory measurements on antihypertensive drug prescriptions at outpatient clinic. Morphological and molecular analysis of neuronal plasticity. Analysis of the interaction between the gastrointestinal microbiota and the immune system.
Improvement of noninvasive diagnosis and therapy of liver diseases. Impact of late-onset Alzheimers risk factor on synapse biology and endocytic trafficking. Insulin and leptin action and mechanisms of action in granulosa cells. Autoimmune and viral models for immune-mediated diseases: multiple sclerosis, myocarditis and inflammatory bowel diseases. Genetic and neuroendocrine contribution to autism spectrum etiology.
Mechanistic investigation of kidney injury. Experimental research in sepsis and mechanisms of controlling the microcirculation physiology. Multicentre and multidisciplinary registry of prospective drug-induced liver injury cases. New advances in photodiagnosis, phototherapy and photoprotection. Effects of the cartilage destruction caused by vitamin D on the patients with osteoarthritis. Stereoscopic image and its applications in Medicine: Skull study with virtual 3D rendering of computed tomography. Preclinical investigation of novel anticancer drugs. Massive rotator cuff tears - when to do what?
Structural basis for increased bone fragility in aging. The effects of melatonin on hepatic regeneration after partial hepatectomy in young and aged sprague-dawley rats. Microenvironment factors in the prognosis of prostate cancer. Identification of unmet therapeutic options due to lack of availability of the most indicated industrial medicine on the market. Nose-to- brain delivery of small molecule drugs: Formulation development studies.
Gene Therapy as a new therapeutic approach for Diabetic Retinopathy. Expression of cysteine protease rCPB2. Effects of mercury exposure in the blood pressure of an academic community. Effects of sodium overload in post natal phase in rats on the hydroelectrolytic balance. Acute oral toxicity, mutagenicity, genotoxicity and embryotoxicity of Ruthenium II complexes in vitro and in vivo assay for the treatment of cancer.
Promoting Food Security. Rab proteins as breast cancer biomarkers. Investigation of inhibition effect of tumor spheroids under alternating electric field. Pesticides and other environmental chemical agents: do they cause pancreatic cancer? Transcription factors as key targets to regulate the selective vulnerability of dopamine neurons. Dimerization of dopamine D3 and acetylcholine nicotinic receptors in the regulation of dopaminergic neurons function: relevance for neurodegeneration in Parkinson's disease. Prevalence of Methicilin resistant Staphylococcus aureus MRSA strains isolated from specimens of the patients admited to National scientific and practical center for Emergency Medicine.
New nutrigenomic approach to investigate the benefits of dairy product consumption on glucose homeostasis. The prevention of diabetes-induce damage of dopaminergic neurons in substantia nigra by polyunsaturated fatty acids in rat model of streptozotocin diabetes mellitus. The international interaction program of natural products and traditional Chinese medicine from bench to clinic. Brain changes in transsexuals, other gender based disorders and other developmental disorders. Study the pattern of complications of new antiviral drugs including hepatocellular carcinoma in Chronic hepatits C virus HCV patients and associated risk factors.
Role of gut microbiome gene 16SrRNA in the pathogenesis of chronic hepatitis C virus and its complications. Cataract Surgery Audit at Benha university hospital; Visual outcome and complications. Reproductive epigenetics affected by endocrine disruptors. Signalling mechanisms regulating adhesion in normal and leukaemia B-cells. Role of macrophages in nervous system conditions. The impact of proton pump inhibitors and statins on pathological response of rectal cancer patients treated with neo-adjuvant chemoradiation followed by surgery.
Molecular study of the stem cell-associated transcription co-factor, ZNF Comparison of myocardial wall thickness on cardiac computed tomography and magnetic resonance imaging. Influence of Whole-Body Electromyostimulation training program on body composition in recreational runners. The Role of Macrophages in Multiple Myeloma and 3D visualization in multiple myeloma bone marrow compartment analysis. Neurobiology of maternal behavior. Neuroanatomy and neurochemistry of motivated maternal care. CD49 expression by flowcytometry and trisomy 12 detection by fluorescent in situ hybridization FISH in chronic lymphocytic leukemia.
Galectin-3 alters the adaptative immune response in Spinal Cord Injury in mice model and promote axonal regeneration. Molecular alterations in hematologic myeloid pathology. Targu Mures Hyperpolarization-activated inward current If blockade — a new approach to lone atrial fibrillation therapy. The utilization of non-invasive cerebral stimulation for smoking cessation.
Complex analysis of hemostasis and fibrinolysis in cancer patients. Influence of murine cytomegalovirus on BV-2 microglial cells.
Computational analysis of interaction between Echinococcus granulosus lipid binding proteins LBPs with variants of vegetable oils using computational chemistry tools, exploring alternative therapies for Hydatid disease. Epidemiological project in public health with emphasis on communicable diseases and noncommunicable diseases.
Immunohistochemical expression of Desmocollin2 and CK14 in urothelial carcinoma. Effect of sitagliptin on cisplatin acute and sub chronic nephrotoxicity in rats. The role of extracellular matrix proteoglycans in diseases. Implantation of neural precursors, derived from human induced pluripotent stem cells, into the brain of the nude rat after experimental traumatic brain injury.
Is alpha-synuclein a neoantigen for the peripheral immune system in Parkinson's disease? Role of Cancer-associated Fibroblasts on Cholangiocarcinoma Progression. Involvement of DDR1 gene variants in myelin integrity and cognitive speed processing in euthymic bipolar disorder patients. Impact of major histocompatibility complex MHC molecule stimulation on gene expression in lymphocytes. Piperine-free Piper nigrum extract: a potent breast cancer preventive supplement.
Physiologic function of spontaneous gastrointestinal and urogenital smooth muscle motility. The role of protein phosphatase 2A for regulation of signaling in the normal and failing heart. The role of tight junction proteins in the pathophysiology of diabetic neuropathy. One layer dunking pancreatojejunostomy vs double layer dunking pancreatojejunostomy during laparoscopic pancreatoduodenectomy.
Evdokimov, Moscow. Peritoneal washing for cancer staging patients with gastric cancer. Role of Sly adaptor proteins in the development of the immune system. Role of the bacterian translocation in the immune reconstitution and clinical resultas after an allogenic hematopoietic stem cell transplant. Molecular analysis of leukemogenesis, particularly Adult T-cell Leukemia in Japan. Talca Role of cellular senescence in platelet aggregation.
Development of fluorescence probe for cancer detection. Characterization of Dengue and Zika viral activities on cellular biology to identify possible strategies to target viral infection or possible uses of those viruses against cancer. A new intracellular monitoring method for Calcinurin-immunosuppressed patients after kidney transplantation. Role of c-Met in Cholangiocarcinoma Invasion. Isolation and analysis of the immune cells from the decidua at term. Determination of synaptic vesicle pools in hippocampal neurons in culture. Streptococcus pneumoniae obtained from carriers: risk factors for colonization, serotypes and effect of valent pneumoccocal conjugate vaccine.
Development of novel rapid fluorescent diagnostic system for human infectious diseases. The target genes identification of MicroRNA associated with colon cancer and their fuctions. Ubiquitin-dependent processes in pathogenesis of Alzheimer's disease. Development of programs of multilevel medical rehabilitation in case of internal organs and systems diseases.
Electrocardiogram findings as predictors of coronary angiography and echo cardio graphic findings in patients with acute ST segment elevation myocardial infarction. Study of the effect of body mass index BMI on the effectiveness of systemic treatment of breast cancerroject. Monitoring of patients suffering from snake bites in the Amazon state.
Study of hypocamphal and cortical oscillations and the participation of gabaergic neurons in experimental model of epilepsy. Nuclear receptors in podocytes as new targets in the kidney failure associated with obesity and typwe 2 diabetes. Characterization of gastrointestinal motility and visceral sensitivity in streptozotocin-induced diabetic rats. Diagnostic Imaging, Cryoablation techniques of tumors in cooperation with Physics Department for the improvement of these techniques. Elucidating the molecular mechanisms linking organelle dysfunction to metabolic diseases. The effect of 5-FU on colonic mucosal inflammation and contractility in mice model.
Studies on the control of cell death by inhibition of lipid peroxidation. Liquid biopsy methods to investigate genetic markers in lung cancer. Role of Androgens in Prostate Cancer Progression. Identification of leukocyte trafficking mechanisms in autoimmune diseases. Patophisiology of multiple myeloma: role of the bone marrow microenvironment. Factors leading to improvement of survival in patients with peripheral arterial disease and diabetes mellitus. Analysis of the gene and protein expressed in the female genital tract with a potential effect on the sperm and fertilization.
Evaluation of the patient's life quality with a tracheostomy. Effect of concurrent aromatase inhibitor with adjuvant radiotherapy on hormone receptor-positive postmenopausal breast cancer patients. Assessment of influence of physical load on the main hemodynamic indicators of medical students. A study on the mechanism of enhanced glutathione export by intracellular cysteine. Resistance of bacterial pathogens to antibiotics and antibiotic therapy of serious infections. Oradea Obstructive Sleep Apnea and comorbid conditions.
Optimizing protocols for beta cell differentiation, regeneration and transplantation via mRNA therapy. Defining drug resistance pathways in the malaria parasite. Candidate genes for control of renal function and arterial blood pressure. Combination of nanoparticle-induced hyperthermia and photodynamic therapy PDT for cancer treatment. Assessment of molecular response to Imatinib therapy in Chronic Myeloid Leukemia patients. Multi-level atlas of the rodent brain: data integration and quantitative analysis.
Influenza virus entry — identification and characterization of host factors. Evaluation of the immune response in T. Right atrial size as a marker for right ventricular function in patients with arrhythmogenic right ventricular cardiomyopathy. Long-term follow up of patients with obstructive pulmonary diseases. Study of properties of causative agents of mycoses and methods of their laboratory diagnosis. Impact of orthognathic surgery on obstructive sleep apnea syndrome. Terminal nerve endings as a biomarker of peripheral neuropathy and reinervation.
Morphometric properties of the tensor fascia lata muscle in human fetuse. The mechanism of antidepressant effect of Glycyl-Glutamine Gly-Gln ; Mediation of serotonergic and glutamatergic neurotransmitter systems in the effect. Mental health of the ageing population in Europe. Genetics, histology and embryology of the cardiovascular system carotid arteries and coronary arteries.
Confocal calcium imaging in acute mouse pancreatic tissue slices.
Unripe banana peel used in peristomaldermatitis. The agreement between auscultation and lung ultrasound and effect of a dry-weight probing guided by lung ultrasound on blood pressure in hemodialysis patients. Anatomical substrates for synchronization between the cingulate and retrosplenial cortices during goal-directed behavior — characterizing neurons with collateralizing axons. Characterization of viscoelastic materials by rheometry to identify parameters affecting blood clot solidity.
Repellent of Melaleuca sp against Aedes aegypti mosquito. Study of the value c-Myc in muscle invasive urotheilal carcinoma of the urinary bludder. Mechanism study of early neurodevelopment and neurological disorders mediated via DNA damage response, protein phosphorylation and RNA methylation. Identifications of the molecular mechanisms responsible for the selective motor neuron death causing amyotrophic lateral sclerosis ALS. Optogenetic interrogation of cognitive brain networks in nonhuman primates. Regulation of Wnt signaling in the articular cartilage: towards better therapy for osteoarthritis.
Novel antibiotics for multidrug resistant bacteria. Preclinical evaluation of medicinal plants for the treatment of chronic inflammatory diseases of the skin. Drug research: from developing experimental models to first in human clinical trials. Genetic polymorphisms associated with asthma. Timisoara The differences that standard intra-operative monitoring offers and what Adequacy of Anesthesia monitoring adds. Timisoara An insight into modern digital pathology diagnosis using Immunohistochemistry techniques.
Preparticipation screening of elite athletes : detection of cardiovascular disease. Ethnopharmacological investigations of the cardiorenal properties of native species from the mesoregion of pantanal, mato grosso do sul state, brazil. Bucharest Imunophenotypic analysis and monitorisation of hematologic neoplasia by flow cytometry.
Craiova Restore cell balance in the perilesional of the aged brain after stroke by direct in vivo reprogramming technology. Bone tissue engineering for large skeletal defects. Study of the tumor immune biology in ovarian cancer patients and development of combined immunotherapy in an ovarian cancer mouse model. Discrimination of roles of activated microglia from those of blood-borne cells in ischemic brains of the rat. Carbon nanotube induced genetic and epigenetic alterations as biomarkers for genotoxic and epigenetic changes. Neuroplasticity during neurodegenerative process. Translational study on the therapeutic effects of a novel class of potent Wnt inhibitors on the pathogenesis of clear cell renal cell carcinoma.
Genetic variants in von Willebrand factor and risk of venous thromboembolism. Bucharest Sleep pathology and its systemic consequences. Investigation of the musculotendinous interconnections between muscles of the anterior compartment of the forearm. Comorbid diagnoses and psychopathological features in Autism Spectrum disorders.
Significance of micronucleus in urothelial lesions and carcinoma. Identification and characterization of bioactive peptide drug candidates from medicinal plants. Association between genetic polymorphisms and Asthma in Ukrainian Adults. Characterization of longevity genes by genome and target sequencing. Study on regulation of neoangigenesis in advanced laryngeal cancer. Gene expression analysis of non-invasive and muscle-invasive bladder tumours for the characterization of aggressive tumour phenotype. Genetic and epigenetic characteristics of breast and ovarian cancer.
Determinants of Optimism in an Austrian cohort. Hemoglobin microparticles — characterization and study of their application as artificial oxygen carriers. Microbiological and Immunobiological aspects in central nervous system infections. Characterization of adult stem cells of dental origin for their differentiation potential and possible practical implications. Molecular profiling of gene expression and epigenetic characterisation of lung cancer cells in Bulgarian patients for identification of possible genetically specific therapies.
Study of adjuvant treatments to conventional treatment debridement of chronic wounds. Antimicrobial multi-resistant bacterial pathogens. Changes to the knee joint during osteoarthritis. Investigation of cellular processes which participate in the anti-tumor response of Calixarene in pancreatic adenocarcinoma cells Panc-1 from analysis of microRNA expression.
Search for natural and synthetic compounds that can lower the inflammatory response in vitro. Detection of mutations causing congenital adrenal hyperplasia. The investigation of cardiotoxicity and risk of developing subsequent heart diseases following breast cancer radiotherapy: a clinical and experimental study. The effect of metformin and aspirin in pancreatic cancer cells in vitro. Prospective survey of acute osteoarticular infections in a Moroccan pediatric orthopedic surgery unit.
Study of Chronic Pulmonary Diseases in Pediatric Patients: bronchiolitis obliterans and cystic fibrosis. Characterization and identification of Th profiles from pregnancy to puerperium. Characterization of the immune mechanisms associated with allergies during pregnancy and their influence in the development of the fetal immune system.
Translational Neuroscience Research in Pain and Itch. Effects of interaction between moesin and CD44 on pericyte loss and immature neovessel formation in diabetes. Analisis of neural circuits of reward and motivation. Peptide antagonists targeting drug resistance associated proteins. Identification of markers of fibrogenesis in alveolar cells in order to identify new therapeutic targets for pulmonary fibrosis. Neuropathology of the trigeminal system in Wfs1 deficiency.
New pharmacological treatments for periferic neuropathic pain. A comparison between urine dipstick test and UCBE urine cytobacteriological examination in the diagnosis of urinary tract infections of newborns 3 months to 24 months. Lumbar punction situation in infant specimen under one year old that show simple feverish convulsion. Next generation sequencing in biomedical field. Role of cell adhesion molecule Neph1 in neural crest cell derivatives. The causes of early fetal loss under polycystic ovary syndrome conditions.
Functional correlates of adult hippocampal cytogenesis: a matter of sex and time. Effects of maternal overnutrition on the epigenetic marks of metabolic programming: identification and potential pharmacological reversibility. Characterization of the relationship between glutaminolysis and autophagy and their influence on acute myeloid leukemia cells. The mechanism study of methylation and Noncoding RNA regulating the shanks expression in epilepsy. Search for Leishmania spp. Mechanistic studies on NOK oncogene related cancer signaling and metabolism. Establishment of Alzheimer Disease model induced by ApoE4 in zebrafish.
Cluj Napoca Single nucleotide polymorphism associations in hyperuricemia and gout. Epidemiology of glaucoma in the capital of Vojvodina, Serbia. Analysis of the Doctor-patient interaction and relationship through a biomedical approach. The preterm brain: define the best model and test therapies to improve prognosis.
Characterization of the role of IL10 on cognitive performance in order to study the relationship between the brain and the immune system. Studies of regulation of brown adipocyte function by mitochondrial homeostasis. Study of the molecular pathogenesis of spinal muscular atrophy SMA in order to identify critical signaling pathways involving in SMA and design new therapeutic approaches to treat SMA. Co-delivery of dual cancer drugs against acute myeloid leukemia.
Methodology research of global burden of diseases GBD. Characterization of prisoner patients with pulmonary tuberculosis in the biggest jail of Ecuador. Synthesizing diversity of cell-topography interaction: a Jungle2jungle initiative. To investigate the role of PSMB8 in invasion and angiogenesis in human glioblastoma cells. Cluj-Napoca Humoral factors in urate-dependent cytokine production. Characterization of intercellular signaling pathways involved in chick lung development. Enhancing iodide-related therapeutic options in thyroid cancer.
Development of malaria parasite with genetically encoded sensors for antimalarial screening and discovery. Characterization of lysossome dysfunction in age-related macular degeneration. Mechanisms of inherited kidney disorders. Heme acquisition and trafficking in pathogenic fungi. Timisoara Correlating heart disease with Toxoplasma infection.
Analysis of life quality in patients with osteoarticular pathologies and learn how to improve it. Assessment of heart rate variability in young hypertensive patients. The correlation of sudden death with Borrelia burgdorferi infection among sudden deaths in Palestine. Diagnostics of intestinal parasitosis in inhabitants of Kujawsko-Pomorskie province in Poland.
Generation and evaluation of bioartificial substitutes for their use as advanced therapy in the surgical repair of critical lesions of the peripheral nerve. Overlap between psychiatric disorders and varieties of substance misuse. Fundamentals of stem cells Regenerative medicine research. Cycling patterns and exposure: A naturalistic study. Livin, a regulator of apoptosis, in health and disease.
Analysis of collective phenomena in pancreatic islets in normal and pathophysiological conditions. Brain-Computer-Interfaces for the restoration and replacement of lost motor function. Influence of psycho-social factors on patients health with cardiac disease. Planing and realization of clinical studies focus lies on heart failure and aterial hypertension. Epigenetic and non-coding RNA Ribonucleic acid regulation during development of the mammalian inner ear: implications for deafness.
Analysis of function of inflammatory cells and cancer cells. The use of Neuroimaging in the study and treatment of Epilepsy. Environmental health and bacterial control analysis. Mesenchymal stem cell MSC isolation and characterization. Diagnostic and therapeutic pathway of pigmented lesions in order to do an earlier diagnosis of melanoma with the use of dermoscopy. Parameters of resistance and reactance of the impulse oscillometry in children aged 3 to 5 years with suspected asthma. Skin inflammation pathways in lupus erythematosus and dermatomyositis. Zika virus vaccines: evaluation of humoral and cellular responses induced by Zika virus vaccines prepared with different adjuvants.
Acetabular index evolution on 4 months to 10 years age children. Eye movement disturbance recorded with eye tracker in patients with focal cervical dystonia. Breast cancer: well known disease with diverse behavior and prognosis-how to diagnose it. Adherence to immunization and to investigate causes of vaccination failure. Features of the clinical course of cystic fibrosis with rare gene mutations. Pathophysiological consequences of lipid raft changes. Genetic analysis of patients with inherited retinal diseases. Effects of oxygen environment on proliferative ability of mammalian developing cardiomyocytes.
I'm from New Jersey, studied neuroscience and philosophy at Haverford College, and confirmed my love for neurology at Harvard Medical School. Apart from the clinical aspects of neurology, I'm interested in research surrounding consciousness, brain networks, and brain stimulation. I'm also interested in the theoretical and ethical problems encountered in neurology, particularly surrounding disorders of consciousness, brain death and diagnostic uncertainty.
I'm a big fan of animals and stand-up comedy too. Louis, MO. My parents are physicians, so it took me a few years of work in engineering before my appropriate fear of medicine was overcome by my interest. I was drawn to neurology by the unusual cases I saw one of my first patients had GABA-B receptor autoimmune encephalitis. I chose Partners for residency because I wanted a large program with multiple hospitals and liked the certificate programs.
Outside of residency I enjoy cooking, rock climbing, and convincing new friends to join me for those activities. I grew up in Maryland but spent most of my adult life in Chicago. I moved to Chicago for college at Northwestern University, where I studied biomedical engineering. During medical school, I fell in love with neurology — both with the fascinating disease processes and the meaningful patient-physician relationships that can be built while caring for such patients. During graduate school, I combined my interest in neuroscience and engineering as I studied electromyogram signal processing for control of robotic prosthetic arms.
I then stayed in Chicago at Northwestern for my intern year in internal medicine. I chose to come to Partners because of its excellent training in clinical neurology, the breadth of research opportunities, and the personable physicians who work and train there. I look forward to exploring neurology and continuing to develop my research interests, with the hopes of eventually started my own translational neural engineering laboratory. I grew up in the suburbs of Boston and am excited to have returned to Boston after more than a decade away.
My undergraduate years first peaked my interest in biological research; my senior thesis studied the use of pheromones in an Arctic seabird. Post-college, my research interests quickly focused on neurology and neurodegenerative disorders. I spent a few years researching common mechanistic pathways in prion diseases, Huntington's disease, and Parkinson's disease. While I anticipate ending up in Movement Disorders or a related neurodegenerative subspecialty, I am so excited to be in the Partners Neurology Residency Program where I will see the true breadth of Neurology surrounded by some of the smartest, most caring and inspiring colleagues.
Out of the hospital, you are most likely to find me outdoors, on a hiking trail with my dog, Scout, or on the soccer field.
COMPUTATIONAL & MATHEMATICAL BIOMEDICAL ENGINEERING
I grew up in Esfahan, a city in central Iran known for its historic architectural marvels. I was interested in science from a very young age, but my fascination with neurology has been many years in the making. I first gained an appreciation for biology and the intricacies of the human brain from my outstanding high school biology teacher. A combination of meaningful patient interactions, volunteering as a Farsi interpreter at UCLA, and my experiences at the UCLA epilepsy clinic sparked my interest in neurology, so I decided to go to medical school.
I was fortunate enough to continue my research endeavors throughout medical school and took a year off to study the role of interneurons in seizure initiation, propagation, and termination; I hope to continue this work during residency. I believe we live at the brink of a revolution in neurology, and I hope to be at the forefront of this movement with a career that integrates research and clinical practice. Moreover, the recent advances in our understanding of the human brain and the sheer number of patients with neurological disorders who are in need of better treatment options have generated a great sense of urgency, promise, and responsibility that I am excited to be a part of as a future neurologist.
What I find most exciting about Partners Neurology is the breadth of clinical experiences at MGH and BWH, and the innumerable research opportunities available in virtually every area of neuroscience and neurology. I have never lived on the East Coast before, but since I moved to the U.
I have been enamored with its history and culture, and residency is the perfect opportunity to explore the Northeast. Ultimately my goal is to run a systems neuroscience laboratory while staying clinically active in the outpatient setting. I spend a lot of my free time with my wife, Neda. We enjoy working out at the gym, hiking, ballroom dancing, and cooking together.
We are also very involved in the Baha'i community and participate in as many community service activities as we can. Oh, and I am also a huge NBA fan and having such a great hometown basketball team is definitely a perk of living in Boston. At MIT I earned a degree in chemical-biological engineering and through my first research experiences there became fascinated with the brain. I worked with several neurologists over the course of my neuroscience research and was soon drawn to medicine -- and of course the neuro exam!
I am excited to be back in Boston for the opportunity to work with the phenomenal neuroscience researchers here, and am now focusing on blood flow dynamics in the brain in vascular disease models. I am particularly interested in the contribution of microischemic events to cognitive decline. Clinically, I am currently most interested in stroke and neurocritical care. Outside of the hospital, I love hiking and backpacking and have been enjoying the proximity to the White Mountains.
I grew up in Monterrey, Mexico where I met my wife and spent the majority of my life. My proudest achievements are my beautiful kids who make everyday a crazy and rewarding adventure. I was drawn to Neurology because I enjoy solving complex mysteries; there is no other specialty or program that can offer this opportunity on a daily basis.
Before coming to Boston I did a postdoctoral fellowship in Neuro-Oncology. With my mentor, Alfredo Quinones-Hinojosa, and multidisciplinary teams we successfully uncovered novel oncogenic pathways, devised three patented nanotechnology-based therapies and a unique diagnostic tool for brain cancer.
My current hobby in the lab is exploring the genomic landscape of brain-specific metastases. Outside of work, I love spending time with my family, exploring the diverse Boston restaurant scene and picking up new hobbies. I am originally from Massachusetts up around the north shore but have been up and down the northeast corridor through my various academic pursuits. Boston will always hold a special place in my heart, and it is good to be back home. I've had an interest in science ever since I was young, and though my undergraduate years that interest crystalized into an active pursuit of all things brain-machine interface and artificial intelligence.
At Drexel, I developed technical skills to sample electrophysiological data from the human drain in-vivo and translate that to develop therapeutically relevant algorithms for the detection so seizure. During that time I grew interested in network level cortical physiology and how the different networks of the brain communicate or fail to communicate and the implications of such on a person functioning in the real world.
My future research goals focus on the fusion of artificial neural networks and in-situ cortical networks to restore lost function and develop new function in human beings. My life consists of 3 different phases in 3 different continents; I was born and raised in U. A for research and medical training.
I have always been fascinated by the brain's complexity and was interested in studying it in depth. I was drawn to Pediatric Neurology when I worked as a clinical research fellow at the University of Pittsburgh in a project that aims to identify the genes for migraine headaches. I moved to New York city to complete 3 years of pediatrics residency training before moving to Boston to embark on the wonderful journey of Neurology.
A career in Pediatric Neurology will allow me to impact the lives of many patients and families with debilitating neurological diseases. Within Neurology, I am interested in Epilepsy disorders in children with specific focus on Epilepsy genetics. In my free time, I like to walk around, relax, listen to classical music and burp my new born baby girl Lina. I also love to travel and meet people from different parts of the world. I was born and raised in Austin, deep in the heart of Texas, and my love for the brain was sparked in a high school anatomy and physiology class.
For college, I headed west to UCLA, where I majored in neuroscience and minored in Germanic Languages, studied abroad in Germany, and developed a love of running, biking, and good beer. I am excited to work towards a career in academic child neurology and developmental neuroscience. I spent the last two years in San Francisco, initially undertaking headache research at Stanford, before completing an intern year at California Pacific Medical Center.
Beyond the hospital, I love travel, music, literature, and exploring this wonderful city. I have had quite an international upbringing! I was born and raised in Stockholm, Sweden, with the exception of a few years of my early childhood, which I spent in Israel. When I was 16, my family moved to Hamilton, Canada. During my undergraduate studies, I developed a passion for chemistry and pursued a Masters in Synthetic Organic Chemistry in Toronto. I am now thrilled to complete my residency in neurology at Partners, a program that offers fantastic opportunities in both research and resident education, as well as a warm and collaborative environment, in what I think is one of the best cities in the world.
I am intrigued by all the mysteries that neurology holds and am very excited to start unraveling them. Going forward, I plan to specialize in outpatient neurology, possibly in Movement Disorders or Multiple Sclerosis, and hope to combine my interests in neurology with the field of Medical Education, in which I am particularly interested in curriculum development. Outside of the hospital, I enjoy running, reading, traveling, and, most importantly, spending time with my loved ones near and far.
Although I am originally from the Washington D. I would visit the city often growing up to see my extended family, and I sometimes tell people that my decision to come here for college was rooted in my love for the show Cheers not totally inaccurate. I attended college and medical school at Boston University through the Seven Year Medical Program, and while I certainly enjoyed many fields of medicine, nothing quite captured my fascination like neurology.
Above all, I am excited about our ability to apply new advancements in basic and clinical science to improve the lives of our patients and their families. Partners was the right choice for me as the program has the breadth and depth of resources to help me pursue my career interests of becoming a physician-educator. Within clinical neurology, my preliminary interests are broad but include movement disorders and neuro-palliative care.
When I am not at work, I enjoy old TV shows and movies, finding great bargains, and cooking new recipes. I think Boston is one of the greatest cities in the world, and I am very excited to work with great colleagues and mentors in this field. I was born in Florida but moved all over the country growing up; my roots are mostly in the Portland and Seattle areas in the Pacific Northwest.
During my PhD training, I studied human movement control and worked with patients with ataxia-telangiectasia, a rare movement disorder, and healthy adults to apply mathematical models to better understand how and why the motor system selects the elegant movement strategies we see every day. I chose the Partners residency program because of the caliber of and camaraderie between residents, as well as the breadth of patients with diverse neurologic disorders that we have the opportunity to see. Outside of work, my interests include hiking and camping, exploring New England, and discovering new restaurants.
I grew up in Baltimore, MD. As an undergrad in Baltimore, I studied philosophy, and wrote my senior thesis on theories of rationality in philosophy of mind. After graduating, I continued my studies in philosophy at the graduate level in Cambridge, England as a Gates Cambridge Scholar, where I focused on philosophical issues relating to medicine and the mind.
My combined interests in philosophy, science and ethics gave rise to my eventual pursuit of medicine, and neurology in particular, at the intersection of these symbiotic domains. During medical school I continued to examine the ethical dimensions and philosophical frameworks underlying standards of care in medicine and public health, and also spent time pursuing empirical research studying genomic drivers of brain tumors. Outside of work I enjoy spending time with family and friends, playing guitar, and exploring the outdoors. I grew up in North Central Florida where I also attended medical school.
No other organ is as personal as the one that creates our unique realities, provides us with imagination, and serves as the curator of our memories. In college, I tried to understand the nervous system at its most basic level through bioelectrics courses in biomedical engineering. Studying the brain in medical school confirmed my love of neuroscience and neurology and gave me a better understanding of the field as it is applied to neurologic disease. I am excited to have matched at Partners Neurology not only for the experience I will gain by working with world experts in the field to take care of complex patients, but also because of the research that will allow the field to grow and advance in novel ways and the welcoming people in the program.
Outside of work, you can find me exploring Boston. I grew up in CT and went to undergrad at Yale, where I studied English and Russian, then spent a year after graduation teaching English in Moscow before heading to a post-bac pre-med program at Bryn Mawr College. I fell in love with clinical neurology during my third year clerkship at Columbia. I love the people and culture at Partners, and I have been so impressed by the breadth of clinical exposure, the kindness and collegiality of the people, and especially the atmosphere of intellectual curiosity.
I am not sure yet what subfield of neurology I want to pursue, but I am interested in palliative care, clinical ethics, and medical humanities. In my spare time, I like rock climbing, playing guitar, and spending time outside in and around Boston, which I've decided is an ideal city! I was born and raised on Long Island, New York, and elected to stay close to home for college. Initially undecided as to my path in life, I chose to enroll at a small liberal arts college. Through a combination of personal and academic experiences in college, along with outstanding mentors, I ultimately decided to pursue a career in medicine.
During my path to medical school, I took two years off after graduation to pursue both teaching and research opportunities before enrolling at Cornell for medical school. Though I entered medical school with an interest in neuroscience, a profound personal experience heightened my interest in the field of neurology, which was only reinforced during my clinical clerkships. I chose to travel a bit further north for residency at Partners due to a variety of factors.
During my interview day, I was consistently taken aback by the warm and welcoming environment of all faculty, staff and current residents, and it was clear to me that such an atmosphere fostered tremendous personal and professional growth among its members. Given the extraordinary resources and breadth of clinical experiences available during the training program, I gained a good sense that this was a program that supported, and encouraged, your interest in any subspecialty of neurology.
Lastly, having come from a relatively small undergraduate and medical school class, mentorship was an important component of residency that I was looking for, and in speaking with current Partners residents, there seemed to be no shortage of willing faculty to support the development of our future careers. Outside of residency, I have a wide variety of interests. I enjoy hiking in all types of environments, with my most recent expedition occurring in the White Mountains, a destination that is exceedingly close to Boston. In addition, during more extended breaks, I find great joy in traveling internationally, having backpacked throughout Europe by myself for a period of several weeks.
Aside from travel, I am an avid carpenter and book reader mainly classics , I enjoy cooking and baking all sorts of food, have an interest in astronomy, and try to spend as much time with family including my dog and friends. I grew up in New Jersey but have lived in Massachusetts for the past 16 years.
During undergraduate, I studied neurobiology and conducted research on rhythmic activity in the thalamic reticular nucleus using patch clamp recordings. In graduate school, I continued with electrophysiology, investigating the role of the dorsolateral prefrontal cortex in risk benefit decision making and later, the contribution of the basolateral amygdala to reward processing. Although I considered all neuro-related specialties throughout medical school which, I could argue, means all specialties , neurology was a natural fit.
I love the sense of mystery in diagnosing neurological problems, and I find our increasing ability to treat such problems incredibly rewarding. I'm most interested in neurocritical care, but I'm trying to keep an open mind since I haven't yet started my neurology years. While the vast array of research labs and resources first attracted me to Partners, it was the excellence and passion of the people at Partners, from students to residents to attendings, who made me want to train here. When not in the hospital, I enjoy traveling, tackling the outdoors with my dog Thunderpaws, and writing science fiction.
I'm one of the rare people who actually enjoys Boston winters- mostly because that means playing ice hockey and skiing - and I have loved living in Cambridge for the past few years. While there I majored in neuroscience and studied executive function in a rat model of schizophrenia. I was also a captain of the track team as a pole vaulter. In the winter, I spent any free weekend days skiing at Mad River Glen. I did research with the NYU concussion center, working on bringing sideline concussion tests into the outpatient clinic.
I was drawn to Partners Neurology because of the breadth and depth of clinic experience, top research opportunities, and the friendly atmosphere. Outside of the hospital I enjoy spending time outside. I made my first foray into the Northeast to attend Dartmouth for undergrad where I majored in neuroscience and classical archaeology. After college, I spent two years working at NIH studying mouse models of drug addiction.
Before starting medical school, I also had the amazing opportunity to lead a Classics study abroad program and travel throughout Greece and the mediterranean for several months. I pursued research in neuroimmunology and global neurology, spending time at a multiple sclerosis clinic in the United Arab Emirates. When applying to residency, I was drawn to Partners due to the breadth of clinical experiences between BWH and MGH, the strong global health network, and because I apparently hadn't gotten my fill of snowstorms during my four years at Dartmouth.
Of note, Boston was not in fact named as one of Americas 10 most haunted towns. When I'm not working, I love biking along the Charles river, exploring the food and beer scene in Boston, and traveling which yes, you actually can manage to do on a resident's salary! I was born and raised in San Diego, California. While the East coast weather never seizes to amaze me, I have fondly made the East coast my home for the past 10 years. My eastward journey began with my undergraduate education at Colgate University, followed by a year in Washington D.
In 12 cases patterns of potentially pathological alpha activity were observed. Three variations of alpha-patterns were described: 1 alpha-rhythm with decreased regional diversity and a marked synchronization in temporal areas; 2 alpha-rhythm with reduced epileptiform complexes integrated into the spindles, 3 decelerated non-rhythmic alpha activity distorted by the higher frequency components. Distinguished varieties of potentially pathological alpha-activity according to their order here represent gradual functional decline of normal thalamo-cortical interaction.
Invasive electrocorticographic monitoring demonstrated that bursts of sharpened polyphasic waves coinciding with alpha-rhythm on scalp EEG are consistent with epileptic discharges on the brain cortex surface. This allows to think of these components as correlates of epileptic activity.
Therefore, on a number of occasions in patients with epilepsy a dissonance between clinical signs and electroencephalographic patterns recorded during restful wakefulness may be observed, when epileptiform components are absent or reduced to nonspecific complexes. Presently, elucidating epilepsy pathogenesis and improvement of its diagnostics and treatment are among the most significant challenges in neurology .
Epilepsy is a relatively widespread condition, with a worldwide incidence rate of 5—10 per people. In the Russian Federation, the estimated incidence of epilepsy is 1. For many years, electroencephalography EEG remains the leading diagnostic method for patients with epilepsy [3, 6, 7], as a majority of patients experiencing regular epileptic seizures exhibit epileptiform activity on EEG.
While the detection of pronounced alpha spindles on EEG indicates well-established adaptive mechanisms for upward and downward regulation, their disappearance demonstrates impaired sensorimotor integration . Nonetheless, alpha range potentials on EEG do not always indicate well-being as they can be detected, for example, in a coma [16, 17]. The detection of alpha activity without epileptiform patterns on EEG significantly reduces the probability of diagnosing epilepsy, assessing its dynamics, and choosing a correct treatment regimen.
Recent studies investigating alpha activity in patients with epilepsy have revealed only a reduction of variability in the frequency of the basic rhythm in these patients . However, despite the apparent role of thalamocortical interactions in spreading epileptic discharges in experimental and mathematical models [2, 9, 20], its pathophysiological aspects are poorly understood to establish unambiguous relationships .
The characteristics of the alpha rhythm and its evolution are currently investigated in the normal EEG and non-epileptic pathological EEG using novel sophisticated methods of data processing [10, 19, 22]. A detailed analysis of alpha activity in patients with epilepsy receiving antiepileptic drugs AEDs will probably enhance the predictive value of EEG for these patients .
This study aimed to assess and systematize EEG patterns with a prevalence of alpha activity in patients with drug-resistant epilepsy. We analyzed the results of comprehensive clinical, neurophysiological, and neuroimaging examination of 50 patients with drug-resistant epilepsy aged between 20 and 55 years. Patients were examined and treated at the Clinic of the Polenov Russian Neurosurgical Institute during — The inclusion criteria in this study were as follows: 1 have focal drug-resistant epilepsy according to the International League Against Epilepsy ILAE criteria treatment with two or more modern AEDs for more than 2 years ; and 2 have stable rhythmic alpha activity on EEG during passive wakefulness.
Neurophysiological examination included conventional EEG with functional tests and long-term video-EEG monitoring during wakefulness and sleep. The surface EEG was recorded in standard leads using monopolar and bipolar montage with electrode locations according to the International 10—20 System. In this study, 12 patients underwent long-term invasive neurophysiological monitoring to verify the location of the epileptic focus. Electrocorticography ECoG was recorded using subdural electrodes in a bipolar montage; the electrodes were introduced through the burr holes. All study participants have had epilepsy for a long time 3—29 years.
The age at the disease onset varied between 1 and 51 years.
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The antiepileptic therapy included at least two modern AEDs, and plasma concentration of the drugs was within the therapeutic reference ranges. Thus, all patients fulfilled the ILAE criteria for drug-resistant epilepsy. In this study, 22 of 50 patients had concordant clinical, neuroimaging, and neurophysiological findings.
In addition, 10 patients exhibited a high index of stable regional epileptic activity along with alpha activity registered by EEG. In 12 patients, both conventional EEG and video-EEG monitoring during passive wakefulness demonstrated only stable alpha activity without any epileptic patterns. Bilateral epileptiform activity was registered in 26 patients using the surface EEG. Furthermore, 14 patients required two or three additional procedures of long-term video-EEG monitoring with a mean duration of 5.
In 13 patients, the sensitivity of video-EEG monitoring was insufficient to identify the location of the epileptic focus; these patients additionally underwent invasive monitoring of the brain bioelectrical activity. Thus, conditionally pathological alpha activity on EEG was observed in 12 of 50 patients with drug-resistant epilepsy Table 1. Of these, 8 patients developed epileptic seizures in childhood at the age of 3—16 years.
Table 1. The characteristics of patients with predominant alpha activity on EEG during wakefulness. Right hippocampal sclerosis, heterotopia at the left lateral ventricle, cystic atrophy of the right frontal lobe. Table 1 shows that we failed to find significant correlations between the clinical manifestations, neuroimaging findings, and the type of EEG changes.
However, we observed some deviations from the normal alpha activity during passive wakefulness. The detected alpha activity differed from the standard alpha activity during passive wakefulness. We identified the following three main variants of conditionally pathological alpha activity Figures 1—3 :.
Figure 2 shows a pattern of the background activity with well-modulated alpha rhythm. Regional high-amplitude sharpened oscillations are registered in the structure of alpha spindles. Usually, such findings are considered as a nonspecific pathological activity. Alpha activity prevailed in the central and temporoparietal leads.
Asynchronous sharpened transients originating primarily from posteriotemporal areas were occasionally registered on EEG. Alpha rhythm with reduced zonal differences and pronounced synchronization in the temporal areas in a year-old male patient with drug-resistant epilepsy. Alpha rhythm with reduced epileptiform elements within the spindles in a year-old female patient with drug-resistant epilepsy. Slow alpha activity distorted by rare high-frequency oscillations sharpened waves in a year-old male patient with drug-resistant epilepsy.