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Calcium channel blockers are the first-choice drugs for angina, but their intravenous administration is contraindicated in newborns and infants [ 17 ]. The use of all the above-mentioned drugs is off-label in KD. Table 6 Long-term therapy for patients with coronary artery aneurysms related to Kawasaki disease and anginal symptoms. I - C Thrombolytic drugs The most commonly administered thrombolytic therapy is intravenous tissue plasminogen activator tPA, alteplase [ 66 — 68 ]. Tissue plasminogen activator Mechanism of action Plasminogen activators are enzymes activating the conversion of plasminogen into plasmin, which can promote clot lysis.

Therapeutic indications KD patients with acute heart attack or intra-aneurysmal thrombi, and KD patients with sudden extension of a thrombus in the coronary artery. Dosage For alteplase: Recommendation 9. I - C Recommendation Invasive cardiologic procedures Interventional catheterization procedures are limited by the large delivery systems for small patients, high risk of complications, and low efficacy, followed by high risk of reintervention. Short-term follow-up Patients with KD must undergo a careful clinical monitoring of blood and instrumental exams in the long-term, but cardiological evaluations with ECG and echocardiography are crucial also in the short-term follow-up.

VI - B Cardiological evaluation performed on the second month since disease onset allows to subdivide KD patients according to the cardiovascular impairment in different risk classes to establish a personalized follow-up. Long-term follow-up Follow-up of KD patients must continue over time, especially for those who have presented CAA, considering that it is not possible to exclude remote complications even in the non-complicated cases. The occurrence of thrombosis or stenosis associated with CAA, in fact, increases the risk of myocardial ischemia. Furthermore, the optimal follow-up of patients with regressed aneurysms remains still controversial since, even with the normalization of vessel diameter, morphological and functional alterations might persist.

Indeed, the normal ultrasound coronary artery framework does not necessarily coincide with the normal endothelial function. This justifies continuing seriated controls, although less frequent, to trace the natural history of the disease, also regarding the possible risk of atherosclerosis.

It is reasonable to use echocardiographic coronary artery luminal dimensions converted to body surface area-adjusted z scores to determine risk stratification of patients [ 81 , 82 ]. Different therapies and follow-up modalities are recommended for each cardiovascular risk class. Table 7 Cardiovascular risk classes in patients with Kawasaki disease.

Reference personnel for patients with a previous KD who want to perform agonistic sports competitive sports or high-intensity activities includes doctors specialized in sports medicine who work in the health systems or in authorized private structures; certification for non-agonistic sports can be provided by the family pediatrician and practitioner In KD patients the evaluation for fitness certification is complicated by several reasons: - there are non-subjective functional limitations patients do not feel sick ; - cardiovascular risks depending on the coronary artery damage is difficult to quantify, and patients affected by giant aneurysms may show normal stress test when myocardial perfusion is evaluated; - few data are available to define exactly risks caused by sport activity; - it is difficult to correlate size of aneurysms to any certification for fitness, though giant or multiple aneurysms should be very carefully evaluated.

Each patient on antiplatelet treatment must avoid contact and collision sports, while patients on anticoagulant therapy must also avoid limited contact sports [ 89 ]. Table 8 Sport classification according to the American Academy of Pediatrics.

Acknowledgements We would like to thank prof. Funding No person who participated in the drafting of these guidelines has been sponsored. Availability of data and materials No datasets were generated or analyzed during the current study. Ethics approval and consent to participate Not applicable.

Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Onofrio n. Eugenio, Rome, Italy.

Postsplenectomy Kawasaki disease in a 17-year‑old male

Diagnosis, treatment, and long-term Management of Kawasaki Disease, a scientific statement for health professionals from the American heart. Arthritis Rheum. The role of infection in Kawasaki syndrome. J Infect. Non-infectious makers of Kawasaki syndrome: tangible or elusive triggers? Immunol Res.

Diagnosis and therapy of Kawasaki disease in children. Diagnosis, treatment, and long-term management in Kawasaki disease: a statement for health professionals from the committee on rheumatic fever, endocarditis and Kawasaki disease, council on cardiovascular disease in the young. American Heart Association. Kawasaki syndrome: an intriguing disease with numerous unsolved dilemmas.

Pediatr Rheumatol. Current recommendations for the pharmacologic therapy in Kawasaki syndrome and management of its cardiovascular complications. Eur Rev Med Pharmacol Sci. Kawasaki disease: insights into pathogenesis and approaches to treatment. Nat Rev Rheumatol. Responsiveness to intravenous immunoglobulins and occurrence of coronary artery abnormalities in a single-center cohort of Italian patients with Kawasaki syndrome.

Rheumatol Int. Clinical features of recurrent Kawasaki disease and its risk factors. Eur J Pediatr.

Intravenous gamma-globulin treatment and retreatment of Kawasaki disease. Pediatr Infect Dis J. Initial intravenous gamma-globulin treatment failure in Kawasaki disease. External validation of a risk score to predict intravenous immunoglobulin resistance in patients with Kawasaki disease. Critical overview of the risk scoring systems to predict non-responsiveness to intravenous immunoglobulin in Kawasaki syndrome. Int J Mol Sci. Pediatric Heart Network Investigators.

Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circ J. Medium-size-vessel vasculitis. Pediatr Nephrol. Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research. Arch Dis Child. Kawasaki disease with severe cardiac sequelae: lessons from recent New Zealand experience. J Paediatr Child Health. Immunohistochemical study of apparently intact coronary artery in a child after Kawasaki disease.

Pediatr Int. The clinical spectrum and treatment options of macrophage activation syndrome in the pediatric age. Macrophage activation syndrome in Kawasaki disease: more common than we thought? Semin Arthritis Rheum. Preliminary diagnostic guidelines for macropphage activation syndrome complicating systemic juvenile arthritis.

J Pediatr. Clinical characteristics of hemophagocytic lymphohistiocytosis following Kawasaki disease: differentiation from recurrent Kawasaki. Blood Res. Recognition of a Kawasaki disease shock syndrome. Google Scholar Rigante D. Autoinflammatory syndromes behind the scenes of recurrent fevers in children. Med Sci Monit. A systematic approach to autoinflammatory syndromes: a spelling booklet for the beginner. Expert Rev Clin Immunol. Pulse methylprednisolone with gammaglobulin as an initial treatment for acute Kawasaki disease. Corticosteroid pulse combination therapy for refractory Kawasaki disease: a randomized trial.

Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease: a prospective, randomised, open, blinded-endpoint trial. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. N Engl J Med. Steroid pulse therapy for Kawasaki disease unresponsive to additional immunoglobulin therapy. Paediatr Child Health. Adverse effects of methylprednisolone pulse therapy in refractory Kawasaki disease.


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Effects of steroid pulse therapy on immunoglobulin-resistant Kawasaki disease. Critical review of efficacy of immunoglobulin plus prednisone for prevention of coronary artery abnormalities in severe Kawasaki disease RAISE study : a randomized, open-label, blinded-endpoints trial. J Popul Ther Clin Pharmacol. Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression. Int J Cardiol. J Immunol. Infliximab for Kawasaki syndrome. Infliximab reduces the cytokine-mediated inflammation but does not suppress cellular infiltration of the vessel wall in refractory Kawasaki disease.

Pediatr Res. Monoclonal antibody therapy for Kawasaki disease: a protocol for systematic reviews and meta-analysis. Syst Rev. Infliximab treatment for refractory Kawasaki syndrome. The effect of TNF-alpha blockade in complicated, refractory Kawasaki disease. Scand J Rheumatol.

Incomplete and atypical Kawasaki disease in a young infant: Severe, recalcitrant disease responsive to infliximab. Clin Pediatr. Infliximab treatment for refractory Kawasaki disease with coronary artery aneurysm. Infliximab treatment in refractory Kawasaki syndrome. Indian J Pediatr. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report. Infliximab is the new kid on the block in Kawasaki disease: a single-centre study over 8 years from North India.

Clin Exp Rheumatol. Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: Report of an open-label case series. J Rheumatol. Primary treatment of incomplete Kawasaki disease with infliximab and methylpredonisolone in a patient with a contraindication to intravenous immune globulin. Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives. Mediators Inflamm.

Pathogenesis of systemic inflammatory diseases in childhood: Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome. Mod Rheumatol. New mosaic tiles in childhood hereditary autoinflammatory disorders. Immunol Lett. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.

Nat Genet. The present state of apheresis results of the survey. Japan Apher Soc. J Am Coll Cardiol. Performance of American Heart Association recommendations for treatment of Kawasaki disease. Kawasaki disease: diagnosis, management, and long-term implications. Cardiol Rev.


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  6. Advances in the treatment of Kawasaki disease. Curr Opin Pediatr. Prevention and treatment of thrombosis in pediatric and congenital heart disease - A scientific statement from the American Heart Association. Long-term anticoagulation in Kawasaki disease: Initial use of low molecular weight heparin is a viable option for patients with severe coronary artery abnormalities. Pediatr Cardiol. Thrombolytic therapy in pediatric patients: a comprehensive review of the literature. Thromb Haemost. Thrombolytic therapy in children. Thromb Res. Thrombolysis in children. Br J Haematol. Management of coronary artery aneurysms using abciximab in children with Kawasaki disease.

    Does abciximab promote coronary artery remodeling in patients with Kawasaki disease? Am J Cardiol. Does abciximab enhance regression of coronary aneurysms resulting from Kawasaki disease? Coronary revascularization in patients with Kawasaki disease. The spectrum of cardiovascular lesions requiring intervention in adults after Kawasaki disease. With partial improvement in his clinical symptoms, he was discharged on oral antibiotics clindamycin and ciprofloxacin , with appropriate outpatient follow-ups.

    The decrease in body temperature was only relative and short as a result of antibiotic treatments. Within 36 hours of his discharge from the hospital, he once again presented with fever, generalized maculopapular erythrodermic rash, oral lesions, sore throat, swollen neck, malaise, and myalgia. He had severe conjunctivitis and edema of the periorbital areas and the eyelids. Cracking and edema of the lips was also evident Figure 1B. There was multiple, painful lymphadenopathy in the anterior and posterior cervical and axillary regions and maximum diameter of 17 mm was reported to be present among the cervical lymph nodes.

    With the exception of tachycardia, the physical examination of the heart, lungs, and abdomen were all unremarkable. No clinical signs of infection in the surgical site were present. There were no clinical signs and symptoms of meningeal irritation.

    [Full text] Postsplenectomy Kawasaki disease in a year‑old male | IMCRJ

    Neurological examination only revealed the peripheral paralysis of the seventh right cranial nerve. Figure 1 The physical examination of patient showed diffused maculopapular erythrodermic rash, and scaling in the distal extremities and around the nails A and severe conjunctivitis of the periorbital and the eyelids and also cracking and edema of the lips B.

    Table 1 Obtained tests during the first 48 hours of hospitalization. Ultrasonography of the abdomen and neck 2 days after hospitalization showed bilateral neck and axillary lymphadenopathy in addition to mild ascites. The size of the liver and pancreas were normal. No pathology in the para-aortic lymph nodes was detected. Echocardiography that was carried out during his second day of hospital stay demonstrated only traces of pericardial fluid, and did not exhibit any signs of cardiac contusion or valvular abnormalities.

    The patient received supportive care, which included IV normal saline, IV antibiotics vancomycin and imipenem , antihistamine loratadine , and acetaminophen. In addition, his erythroderma and scaling were further intensified Figure 1A. Prior to IVIG administration and despite the treatment with acetaminophen and antibiotics, the patient remained pyretic. After 2 days of IVIG treatment, the fever as well as the pain in the lymph nodes subsided. After 4 days and a total received dosage of g, IVIG administration was discontinued.

    Given his remarkable clinical improvement, after 4 days, his IVIG treatment was discontinued. His echocardiogram and coronary angiography that were carried out on the 14th and 20th day of his admission, respectively, reported normal and showed no signs of coronary artery aneurysm Figure 3. Figure 2 The physical examination of patient was normal 10 days after admission and his lymphadenopathies resolved. Figure 3 Echocardiogram and coronary angiography of patient reported normal and showed no signs of coronary artery aneurysm.

    Written informed consent of the patient was obtained to publish this case report. Simultaneous occurrence of fever and skin rash is a common and challenging clinical presentation in both pediatric and adult patients. Although the differential diagnosis is very broad, adequate history and physical examination may help the clinician to narrow down a potential list of probable etiologies. Since the spectrum of diagnosis can include mild self-limiting condition to life-threatening disease, clinical discretion remains imperative.

    In our patient, the presentation of fever and mucocutaneous rash, postsplenectomy, led to clinical suspicion for the diagnosis of sepsis and toxic shock syndrome. Yet, the negative result of blood cultures and lack of response to antibiotic treatments as well as clinical features not consistent with infectious etiologies led to the consideration of other alternative diagnoses. Moreover, the use of phenytoin in the patient, led to the consideration of drug reaction as an alternative diagnosis, which could have presented in a clinical spectrum from mild-to-severe reaction, such as that seen in Steven—Johnson syndrome SJS.

    Case Report ARTICLE

    However, the presence of thrombocytosis and diffuse desquamation was against this diagnosis. The diagnosis of SJS or toxic epidermal necrolysis is not plausible. Fever is not a primary feature of these diseases and systemic reactions, such as increased white blood cell count, elevated ESR, positive CRP levels, and thrombocytosis are not expected to occur with this degree and severity; edema of the extremities, scaling, and the absence of target lesions are supportive of the diagnoses other than SJS.

    Thus, by considering all of the signs and symptoms in the patient and fulfillment of the diagnostic criteria for the Kawasaki syndrome, clinical diagnosis was made, and patient was started on appropriate therapy, which led to an uneventful course of recovery. Given that prevalence of Kawasaki syndrome remains low, high index of clinical suspicion and application of the diagnostic criteria for this potentially treatable disease remain invaluable. Early diagnosis and effective therapy with IVIG have been shown to significantly reduce the morbidity and mortality from this disease.

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